1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine

Name	WAY-262611
Synonyms	DKK1 MAY-262611 WAY-262611 1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine 1-{1-[4-(2-Naphthyl)-2-pyrimidinyl]-4-piperidinyl}methanamine 4-PiperidineMethanaMine, 1-[4-(2-naphthalenyl)-2-pyriMidinyl]- 1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine MAY-262611
CAS	1123231-07-1
EINECS	604-604-1

Molecular Formula	C20H22N4
Molar Mass	318.42
Density	1.169±0.06 g/cm3(Predicted)
Boling Point	544.8±42.0 °C(Predicted)
Solubility	DMSO: ≥ 42 mg/mL
pKa	10.13±0.29(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
In vitro study	WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility.
In vivo study	WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β -catenin pathway and most likely through inhibition of Dkk-1.

Last Update：2024-01-02 23:10:35

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CAS: 1123231-07-1
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Product Name: WAY-262611 Visit Supplier Webpage Request for quotation
CAS: 1123231-07-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine Request for Quotation